WP07 - Outcome assessment - NIRS


Workpackage lead and partners:

WP leader:
Prof. Gunnar Naulaers, K.U.Leuven

WP partners:

Workpackage objectives: 

  • To use NIRS as a tool for diagnosis and evaluation of treatment in hypotension in VLBW infants
  • To describe the effects of dopamine on the cerebral oxygenation as assessed by NIRS.
  • To measure autoregulation and the effect of dopamine on autoregulation. 

Workpackage description:

Task 1: Setting up Expert Group/ SOP

To use NIRS as a tool for diagnosis and evaluation of treatment in hypotension in VLBW infants.

1a. Organising a discussion forum regarding the use of NIRS in hypotension.

The goal of this part of the study is to find out whether NIRS can be used as a monitor that guides us in the decision regarding treatment of neonatal hypotension. Therefore a discussion forum will be organised with the participating centres.

1b. Review of the NIRS data to make decision patterns describing the use of NIRS in the evaluation of hypotension in VLBW infants:

The different NIRS data will be collected and processed by Joke Vanderhaegen and Alexander Caicedo in Leuven. The effect of the medication on the blood pressure and the cerebral oxygenation will be compared, in order to detect whether the NIRS-monitoring is not a better way to look at the effects of medication than blood pressure monitoring alone. Importantly, the NIRS measurements will not affect treatment. So treatment will not be adapted to NIRS-values but only to the blood pressure values. A hypothesis will be made to study whether treatment would have been different if NIRS-values are used.

1c. As there is also a follow-up planned, the relation between NIRS values and outcome will be studied more in detail whether to define the lowest values of cerebral oxygenation. The comparison between treating according to blood pressure values