The HIP Trial has two main objectives.

 

The primary objective is to determine whether, in infants born before 28 completed weeks of gestation, a restricted approach to the management of hypotension compared to using dopamine as a first line inotrope within the first 72 hrs improves:

  • Survival without significant brain injury at 36 weeks corrected gestational age.
  • Survival without neurodevelopmental disability at 2 years age corrected for prematurity.

 

The secondary objective is to determine whether a restricted approach to the management of hypotension compared to using dopamine as a first line intorope affects:

  • All cause mortality at 36 weeks gestational age.
  • The incidence of severe abnormality (grade III-IV intraventricular  haemorrhage, cystic periventricular leukomalacia or ventricular dilatation) detected on serial cranial ultrasound examinations.
  • The number of adverse effects attributable to treatment.
  • Individual impairments at 2 years corrected age.
  • Developmental and behavioural scores at 2 years corrected age.
premature baby