WP14 - Systematic Literature Review Dopamine for the Treatment of Circulatory Instability beyond the neonatal period


Workpackage lead and partners:

WP leader:
Dr. Keith Barrington, CHU

WP partners:

Workpackage objectives: 

    • To determine the most common causes of circulatory instability in the pediatric population
    • To determine the safety and efficacy of dopamine use in the pediatric population through a series of systematic reviews of the pediatric literature

    Workpackage description:

    This work package will provide a framework for increasing the information available on the use of dopamine in the paediatric population. There are many reasons for circulatory instability in this population. These reasons will be explored and the use of dopamine for these indications, in the form of randomized controlled trials, will be
    explored and quantitative systematic reviews will be performed where appropriate.
    This work package will be led by Professor Keith Barrington of CHU Centre Hospitalier Universitaire Sainte-Justine (CR04) with input from KU Leuven (CR02), Royal College of Surgeons in Ireland (CR 13), University College Dublin (CR05), and University College Cork (CR01).

    Task 1: To establish the causes of circulatory instability in the pediatric population

    A thorough review of the literature will be performed to determine the aetiology of paediatric shock and other conditions where dopamine is currently used or recommended. Search terms will be defined and reviews will be performed by three independent reviewers. Results will be collated and a consensus will be reached by the three reviewers to determine the cases of paediatric shock, and the commonest indications for the use of dopamine These defined causes will then be explored in Task 3.

    Task 2: To develop a standardised approach to the performance of systematic reviews

    Performance of systematic reviews will be based on criteria set out by the Cochrane review group. The title and the abstracts of studies identified by the search strategy will be assessed for eligibility to be included into the review by the review authors independently. The full text version will be obtained for assessment. Differences will be resolved by discussion. Where any queries arise or where additional data are required, the relevant authors will be contacted. The standardized review methods of the Cochrane Neonatal Review Group (CNRG) will be used to assess the methodological quality of the studies. Reviewers will
    independently assess the quality of the included studies using the standard criteria developed by the CNRG. The handbook of the Cochrane collaboration will be used a source of standards.

    Task 3: To establish the efficacy of dopamine in the treatment of pediatric shock

    For each of the conditions and indications established in Task 1, a systematic review will be performed: Search terms will be defined and clinically important outcomes will be determined. Then, specific groups will be established for each review and will perform independent reviews according to the standards agreed in Task 2.
    And meta-analysis will be performed where possible to determine the treatment effect of dopamine in specific conditions (e. g. circulatory failure secondary to sepsis) in improving survival and other clinically important results.